Cannabidiol, also known as CBD, is one of the two active components of the cannabis plant. This compound is growing in popularity because of the wide variety of benefits it can offer. It’s been found to help regulate the production of cortisol, oxytocin, and serotonin, which can help with mental conditions such as anxiety [1] and depression [2]. Unlike its other half, Tetrahydrocannabinol (THC), CBD doesn’t have any psychoactive properties. [3] This means that it won’t intoxicate the user in any way. Additionally, CBD has recently been found to have a potent anti-inflammatory effect. [4] If you’re looking for non-invasive treatment for any inflammation-related conditions, CBD may be the best option for you.
How does CBD work?
The human body produces a couple of different strains of cannabinoids, which explains why there are cannabinoid receptors in our system. These receptors help us to synthesize the CBD particles more efficiently, leading to a more potent effect than many other natural alternatives. The endocannabinoid system is responsible for the handling and breaking down of CBD particles, and it’s comprised of two types of receptors: CB1 and CB2. These receptors are found in almost every cell in our bodies.
The Symptoms of Inflammation
Inflammation is our body’s way of responding to any intruding particles, contaminants, and germs. [5] The classic symptoms of inflammation include redness, swelling, heat, and sharp pain. Although we may see it as a nuisance or inconvenience, inflammation is a crucial physiological response that helps us to survive against microscopic threats that enter our bodies. It’s a sign that our immune system has targeted the injured area and that the healing process is underway. However, the problem is that when the inflammation is persistent and severe, it can result in a number of chronic conditions. For example, conditions such as rheumatoid arthritis, coeliac disease, and even certain types of cancers are caused by chronic inflammation of the cells. Some inflammatory-related diseases are caused by the excessive-hyperactive immune system, as the system will perceive everything as a threat and attempts to eliminate it, including the healthy cells. This condition is known as autoimmune disease, and such conditions are usually genetic. [6]
How CBD treats inflammation
As mentioned, CBD has a potent anti-inflammatory effect, and it has been supported in many parts of the medical community in recent years. The treatment has shown to be effective at alleviating the severity of autoimmune diseases by reducing the hyperactivity of the white blood cells. CBD can also help to soothe the pain, swelling, and heat of the inflamed area, making it an effective pain reliever. [7] In addition to this, CBD has also been found to be an effective treatment for neuropathic pain [8], hypertension [9], and Alzheimer’s disease [10]. This makes it a potent medication all around. A large part of the medical field has been pushing for CBD to be recognized as a standardized treatment for these conditions, and the future of CBD users is looking bright with each new publication.
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References:
1. Schier, Alexandre Rafael De Mello, et al. “Cannabidiol, a Cannabis Sativa Constituent, as an Anxiolytic Drug.” Revista Brasileira De Psiquiatria, vol. 34, 2012, doi:10.1590/s1516-44462012000500008.
2. Durst, Ronen, et al. “Cannabidiol, a Nonpsychoactive Cannabis Constituent, Protects against Myocardial Ischemic Reperfusion Injury.” American Journal of Physiology-Heart and Circulatory Physiology, vol. 293, no. 6, 2007, doi:10.1152/ajpheart.00098.2007.
3. Iseger, Tabitha A., and Matthijs G. Bossong. “A Systematic Review of the Antipsychotic Properties of Cannabidiol in Humans.” Schizophrenia Research, vol. 162, no. 1-3, 2015, pp. 153–161., doi:10.1016/j.schres.2015.01.033.
4. Sharma, Manju, et al. “East Indian Sandalwood Oil (EISO) Alleviates Inflammatory and Proliferative Pathologies of Psoriasis.” Frontiers in Pharmacology, vol. 8, 2017, doi:10.3389/fphar.2017.00125.
5. “What Is an Inflammation?” Current Neurology and Neuroscience Reports., U.S. National Library of Medicine, 22 Feb. 2018, www.ncbi.nlm.nih.gov/books/NBK279298/.
6. “Autoimmune Disorders: MedlinePlus Medical Encyclopedia.” MedlinePlus, U.S. National Library of Medicine, medlineplus.gov/ency/article/000816.htm.
7. Mouslech, Z, and V Valla. “Endocannabinoid System: An Overview of Its Potential in Current Medical Practice.” Current Neurology and Neuroscience Reports., U.S. National Library of Medicine, www.ncbi.nlm.nih.gov/pubmed/19675519.
8. Xiong, Wei, et al. “Cannabinoids Suppress Inflammatory and Neuropathic Pain by Targeting α3 Glycine Receptors.” The Journal of Experimental Medicine, vol. 209, no. 6, 2012, pp. 1121–1134., doi:10.1084/jem.20120242.
9. Malinowska, Barbara, et al. “Cannabinoids in Arterial, Pulmonary and Portal Hypertension - Mechanisms of Action and Potential Therapeutic Significance.” British Journal of Pharmacology, 2018, doi:10.1111/bph.14168.
10. Kogan, N M, and R Mechoulam. “Cannabinoids in Health and Disease.” Current Neurology and Neuroscience Reports., U.S. National Library of Medicine, www.ncbi.nlm.nih.gov/pubmed/18286801.